کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1373835 981908 2006 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Facile synthesis of substituted thiophenes via Pd/C-mediated sonogashira coupling in water
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Facile synthesis of substituted thiophenes via Pd/C-mediated sonogashira coupling in water
چکیده انگلیسی

The first successful Pd/C-mediated Sonogashira coupling of iodothiophene with terminal alkynes in water is described here. Pd/C-CuI-PPh3 was found to be an efficient catalyst system for this coupling reaction. Using this economic and reliable process a variety of acetylenic thiophenes with a wide range of functional groups were prepared in good yields. Synthetic applications and in vitro anticancer properties of some of the compounds synthesized are described.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 24, 15 December 2006, Pages 6185–6189
نویسندگان
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