Discovery of 4-azaindoles as novel inhibitors of c-Met kinase

A series of 4-azaindole inhibitors of c-Met kinase is described. The postulated binding mode was confirmed by an X-ray crystal structure and series optimisation was performed on the basis of this structure. Future directions for series development are discussed.

The SAR and X-ray crystal structure of a series of 4-azaindole inhibitors of c-Met kinase is reported.Figure optionsDownload as PowerPoint slide