Bio-inspired synthesis and biological evaluation of a colchicine-related compound library

A bio-inspired investigation of the reactions of substrates of type 1 with VOF3 and PIFA [phenyliodine(III) bis(trifluoroacetate)] led to a collection of colchicine-like compounds 2–5 and related systems. Biological evaluation revealed that some of the synthesized products had significant cytotoxic properties against the colon cancer cell line HT-29.

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