کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1374117 981913 2006 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis of highly substituted dibenzo[b,f]azocines and their evaluation as protein kinase inhibitors
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis of highly substituted dibenzo[b,f]azocines and their evaluation as protein kinase inhibitors
چکیده انگلیسی

Synthetic routes towards highly substituted eight membered ring heterocycles fused to aryl rings such as the dibenzo[b,f]azocine system are still lacking. Herein, we present a convenient convergent synthetic route towards this heterocyclic class of compounds with possible variations at positions 4, 7, and 11. One member of a library of dibenzo[b,f]azocines with different substituents at position 11 was identified to inhibit protein kinase A activity (IC50 = 122 μM) but not protein kinase C.

Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 20, 15 October 2006, Pages 5360–5363
نویسندگان
, ,