کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1374118 981913 2006 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Phosphodiester modification by zinc metalated adenine polymer with carboxyl pendants
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Phosphodiester modification by zinc metalated adenine polymer with carboxyl pendants
چکیده انگلیسی

This report describes a novel carboxyl pendant containing adenylated polymeric template, its metalation with Zn (II), and manifestation of catalytic activity for the hydrolysis of model phosphodiester, bis(p-nitrophenyl) phosphate (bNPP), and plasmid cleavage. Observation of a bell-shaped pH-Kobs profile suggested influence of pH variation over hydrolysis rate. This metalated polymer also afforded facile relaxation of pBR322 supercoiled DNA, with an interesting reusability feature intricately associated with heterogeneous catalysis.

Phosphate ester hydrolysis and plasmid relaxation by metalated modified adenine polymer containing carboxyl group appendages is reported.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 20, 15 October 2006, Pages 5364–5367
نویسندگان
, , , ,