Atropisomeric small molecule Bcl-2 ligands: Determination of bioactive conformation

The separation of atropisomeric conformers of 1,2,3,4-tetrahydroisoquinoline amide Bcl-2 ligands allowed the identification of the bioactive conformer which was subsequently confirmed by X-ray crystallography.

Determination of the bioactive conformation of a series of atropisomeric Bcl-2 inhibitors is reported.Figure optionsDownload as PowerPoint slide