کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1374212 981914 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Stereoselective synthesis of 15- and 16-substituted isosteviol derivatives and their cytotoxic activities
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Stereoselective synthesis of 15- and 16-substituted isosteviol derivatives and their cytotoxic activities
چکیده انگلیسی

By means of functional interconversions in ring D of the tetracyclic diterpene isosteviol (ent-16-ketobeyeran-19-oic acid 1), various 15- and 16-substituted isosteviol derivatives were stereoselectively prepared. The cytotoxic activities in vitro of these new isosteviol derivatives were investigated, and some of them showed noteworthy activities against B16-F10 melanoma cells.

A novel series of 15- and 16-substituted isosteviol derivatives were designed and prepared. Within all compounds, 22 (IC50 = 15 μM) showed the most potent cytotoxic activities against B16-F10 melanoma cells.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 19, Issue 6, 15 March 2009, Pages 1818–1821
نویسندگان
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