کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1374212 | 981914 | 2009 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Stereoselective synthesis of 15- and 16-substituted isosteviol derivatives and their cytotoxic activities
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
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چکیده انگلیسی
By means of functional interconversions in ring D of the tetracyclic diterpene isosteviol (ent-16-ketobeyeran-19-oic acid 1), various 15- and 16-substituted isosteviol derivatives were stereoselectively prepared. The cytotoxic activities in vitro of these new isosteviol derivatives were investigated, and some of them showed noteworthy activities against B16-F10 melanoma cells.
A novel series of 15- and 16-substituted isosteviol derivatives were designed and prepared. Within all compounds, 22 (IC50 = 15 μM) showed the most potent cytotoxic activities against B16-F10 melanoma cells.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 19, Issue 6, 15 March 2009, Pages 1818–1821
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 19, Issue 6, 15 March 2009, Pages 1818–1821
نویسندگان
Ya Wu, Gui-Fu Dai, Jing-Hua Yang, Yun-Xiao Zhang, Yu Zhu, Jing-Chao Tao,