کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1374373 981918 2006 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Osteoblast differentiation stimulating activity of biflavonoids from Cephalotaxus koreana
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Osteoblast differentiation stimulating activity of biflavonoids from Cephalotaxus koreana
چکیده انگلیسی

Six amentoflavone-type biflavonoids, bilobetin (1), ginkgetin (2), 4′,7″-di-O-methyl-amentoflavone (3), 7-O-methyl-isoginkgetin (4), sciadopitysin (5), and 7,4′,7″,4‴-O-methyl-amentoflavone (6), were isolated from the EtOAc fraction of Cephalotaxus koreana Nakai (Cephalotaxaceae) by bioactivity-guided fractionation technique using primary cultures of mouse osteoblasts as an in vitro assay system. Among the six biflavonoids isolated, bilobetin (1), sciadopitysin (5), and 7,4′,7″,4‴-O-methyl-amentoflavone (6) significantly increased osteoblast differentiation as assessed by alkaline phosphatase activity, collagen synthesis, and mineralization. Considering structure–activity relationship, methoxyl groups at 4′ and 4‴ in the B rings in amentoflavone-type biflavonoid might be important in osteoblast differentiation. Taken together, our present study suggests therapeutic potential of biflavonoids against bone diseases such as osteoporosis.

Bilobetin (1), sciadopitysin (5), and 7,4′,7″,4‴-O-methyl-amentoflavone (6), biflavonoids isolated from Cephalotaxus koreana increased osteoblast differentiation.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 11, 1 June 2006, Pages 2850–2854
نویسندگان
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