کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1374373 | 981918 | 2006 | 5 صفحه PDF | دانلود رایگان |

Six amentoflavone-type biflavonoids, bilobetin (1), ginkgetin (2), 4′,7″-di-O-methyl-amentoflavone (3), 7-O-methyl-isoginkgetin (4), sciadopitysin (5), and 7,4′,7″,4‴-O-methyl-amentoflavone (6), were isolated from the EtOAc fraction of Cephalotaxus koreana Nakai (Cephalotaxaceae) by bioactivity-guided fractionation technique using primary cultures of mouse osteoblasts as an in vitro assay system. Among the six biflavonoids isolated, bilobetin (1), sciadopitysin (5), and 7,4′,7″,4‴-O-methyl-amentoflavone (6) significantly increased osteoblast differentiation as assessed by alkaline phosphatase activity, collagen synthesis, and mineralization. Considering structure–activity relationship, methoxyl groups at 4′ and 4‴ in the B rings in amentoflavone-type biflavonoid might be important in osteoblast differentiation. Taken together, our present study suggests therapeutic potential of biflavonoids against bone diseases such as osteoporosis.
Bilobetin (1), sciadopitysin (5), and 7,4′,7″,4‴-O-methyl-amentoflavone (6), biflavonoids isolated from Cephalotaxus koreana increased osteoblast differentiation.Figure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 11, 1 June 2006, Pages 2850–2854