کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1374410 981918 2006 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Activation of mitogen activated protein kinase (MAPK) during d-galactosamine intoxication in the rat liver
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Activation of mitogen activated protein kinase (MAPK) during d-galactosamine intoxication in the rat liver
چکیده انگلیسی

A significant increase in plasma glutamate-oxaloacetate transaminase and glutamate-pyruvate transaminase was observed 6 h after intraperitoneal administration of d-galactosamine (d-Galn). Three hours after administration of d-Galn, the vitamin C concentration in the liver decreased significantly compared to that in a control group and thereafter the hepatic vitamin C concentration remained at a significantly lower level. Phosphorylated JNK (c-Jun NH2-terminal kinase) and phosphorylated ERK (extracellular signal-regulated kinase) started increasing 3 h after d-Galn treatment and remained at a high level for 6–12 h after the treatment, while phosphorylated p38 MAPK increased significantly 6 h after d-Galn administration. These results indicated that oxidative stress and the activation of JNK and ERK took place almost simultaneously, followed by the activation of p38 MAPK.

Oxidative stress and the activation of JNK and ERK took place almost simultaneously in the rat liver by intraperitoneal administration of d-galactosamine, followed by the activation of p38 MAPK.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 11, 1 June 2006, Pages 3019–3022
نویسندگان
, , , , , ,