کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1374417 981918 2006 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
SAR studies: Designing potent and selective LXR agonists
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
SAR studies: Designing potent and selective LXR agonists
چکیده انگلیسی

Counterscreening compounds from a Merck PPAR program discovered lead 1, as a nanomolar LXR/PPAR dual agonist. SAR optimization developed a series of heterocyclic LXR agonists having excellent selectivity over all PPAR isoforms and possessing high LXR affinity and strong in vivo potency.

Lead screening at Merck identified a potent, dual LXR/PPAR agonist. SAR optimization developed a series of LXR specific heterocyclic agonists having excellent LXR affinity, good in vivo, potency and high selectivity versus other nuclear hormone receptors.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 11, 1 June 2006, Pages 3055–3060
نویسندگان
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