کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1374438 | 981919 | 2009 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The design and discovery of novel amide CCR5 antagonists
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The design and discovery of novel amide CCR5 antagonists The design and discovery of novel amide CCR5 antagonists](/preview/png/1374438.png)
چکیده انگلیسی
The synthesis of a range of novel amine-containing structures and their primary potency as inhibitors of HIV-1 fusion via blocking of the CCR5 receptor is described. The development of the medicinal chemistry strategy and SAR’s which led to the identification of the piperidine amide compounds 33 and 36 as excellent leads for further evaluation is described, along with key physicochemical data which highlighted their lead potential.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 19, Issue 4, 15 February 2009, Pages 1084–1088
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 19, Issue 4, 15 February 2009, Pages 1084–1088
نویسندگان
David C. Pryde, Martin Corless, David R. Fenwick, Helen J. Mason, Blanda C. Stammen, Peter T. Stephenson, David Ellis, David Bachelor, David Gordon, Christopher G. Barber, Anthony Wood, Donald S. Middleton, David C. Blakemore, Gemma C. Parsons,