Biosynthetic studies of spiroleptosphol

Studies of the biosynthesis of spiroleptosphol (1) revealed that 1 comprised a heptaketide (C1, C5-C10, and C12-C18 moiety), two methyl carbons (C19 and C20) from methionine, and a C3 unit (C3, C4, and C11 moiety) derived through the TCA cycle.