Discovery of 2-(α-methylbenzylamino) pyrazines as potent Type II inhibitors of FMS

A series of 2-(α-methylbenzylamino) pyrazines have shown to be potent inhibitors of the FMS tyrosine receptor kinase. Details of SAR studies, modeling and synthesis of compounds within this series are reported.

A novel series of 2-(α-methylbenzylamino) pyrazines have been synthesized and shown to be potent inhibitors of the FMS tyrosine receptor kinase.Figure optionsDownload as PowerPoint slide