کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1374685 981922 2010 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis of new oxathiazinane dioxides and their in vitro cancer cell growth inhibitory activity
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis of new oxathiazinane dioxides and their in vitro cancer cell growth inhibitory activity
چکیده انگلیسی

New oxathiazinane dioxides have been derived from d- and l-serine and tested for their in vitro cell growth inhibitory activity toward SKBR3 breast cancer cells. (5R)-5-(4-(4′-Bromomethyl)phenyl)benzyloxymethyl-[1,3,4]-oxathiazinane-3,3-dioxide showed a cytotoxicity of IC50 ≈ 10 μM.

New oxathiazinane dioxides derived from d- and l-serine have been tested for their in vitro cell growth inhibitory activity toward SKBR3 breast cancer cells. Compound (R)-24 (R′ = BrCH2C6H4-C6H4CH2) showed a cytotoxicity with IC50 ≅ 10 μM.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 20, Issue 17, 1 September 2010, Pages 5353–5356
نویسندگان
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