کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1374698 981923 2006 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and structure–activity relationships of novel dipeptides and reduced dipeptides as ligands for melanocortin subtype-4 receptor
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis and structure–activity relationships of novel dipeptides and reduced dipeptides as ligands for melanocortin subtype-4 receptor
چکیده انگلیسی

A series of benzylic piperazines (e.g., 4 and 5) attached to an ‘address element’, the dipeptide H-d-Tic-d-p-Cl-Phe-OH, 3 has been identified as ligands for the melanocortin subtype-4 receptor (MC4R). We describe herein the structure–activity relationship (SAR) studies on the N-terminal residue of the ‘address element’. Several novel dipeptides and reduced dipeptides with high MC4R binding affinities and selectivity emerged from this SAR study.

The synthesis and SAR studies on the N-terminal residue of the ‘address element’ are reported.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 9, 1 May 2006, Pages 2341–2346
نویسندگان
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