Substituted coumarins as potent 5-lipoxygenase inhibitors

Leukotriene biosynthesis inhibitors have potential as therapeutic agents for asthma and inflammatory diseases. A novel series of substituted coumarin derivatives has been synthesized and the structure–activity relationship was evaluated with respect to their ability to inhibit the formation of leukotrienes via the human 5-lipoxygenase enzyme.

A novel series of substituted coumarin derivatives has been synthesized. SAR studies in this series led to the identification of inhibitor 1.Figure optionsDownload as PowerPoint slide