Novel oxime and oxime ether derivatives of 12,14-dichlorodehydroabietic acid: Design, synthesis, and BK channel-opening activity

Oxime ether derivatives of the benzylic ketone of 12,14-dichlorodehydroabietic acid (diCl-DHAA, 4b) were synthesised, and their BK channel-opening activity was evaluated in an assay system of CHO-K1 cells expressing hBKα channels. Oxime ether structure on the B ring of diCl-DHAA significantly increased the BK channel-opening activity.

The oxime ether structure, particularly when bearing O-short carbon chains, significantly increased the BK channel-opening activity of 12,14-dichlorodehydroabietic acid (4b).Figure optionsDownload as PowerPoint slide