Chroman-3-amides as potent Rho kinase inhibitors

Inhibition of Rho kinase (ROCK) is an attractive strategy for the treatment of diseases such as hypertension, glaucoma, and cancer. Here we report chroman-3-amides as highly potent ROCK inhibitors with sufficient kinase selectivity, excellent cell activity, good microsomal stability, and desirable pharmacokinetic properties for study as potential therapeutic agents.

Here we report chroman-3-amides as potent ROCK inhibitors with sufficient kinase selectivity, cell permeability, stability, and desirable pharmacokinetic properties for study as potential therapeutic agents.Figure optionsDownload as PowerPoint slide