کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1374911 981927 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
5-Fluorocytosine derivatives as inhibitors of deoxycytidine kinase
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
5-Fluorocytosine derivatives as inhibitors of deoxycytidine kinase
چکیده انگلیسی

A series of potent piperidine-linked cytosine derivatives were prepared as inhibitors of deoxycytidine kinase (dCK). Compound 9h was discovered to be a potent inhibitor of dCK and shows a good combination of cellular potency and pharmacokinetic parameters. Compound 9h blocks the incorporation of radiolabeled cytosine into mouse T-cells in vitro, as well as in vivo in mice following a T-cell challenge.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 19, Issue 23, 1 December 2009, Pages 6780–6783
نویسندگان
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