کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1374943 981928 2006 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Methylated β-cyclodextrin as P-gp modulators for deliverance of doxorubicin across an in vitro model of blood–brain barrier
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Methylated β-cyclodextrin as P-gp modulators for deliverance of doxorubicin across an in vitro model of blood–brain barrier
چکیده انگلیسی

Co-incubations of various β-cyclodextrins and doxorubicin have been evaluated on an in vitro model of blood–brain barrier in order to increase the delivery of this P-gp substrate to the brain. Among these cyclodextrins used, the Rame-β-cyclodextrin and Crysme-β-cyclodextrin increased the transport by a factor of 2 and 3.7, respectively. This increase was attributed to the cholesterol extraction property of these cyclodextrins from brain capillary endothelial cells leading to a modulation of the P-gp activity.

Methylated β-cyclodextrins (CDs) are used to increase the brain delivery of doxorubicin (DOX) by modifying the P-gp activity.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 8, 15 April 2006, Pages 2154–2157
نویسندگان
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