2-Aryloxymethylmorpholine histamine H3 antagonists

The synthesis and biological activity of a new series of 2-aryloxymethylmorpholine histamine H3 antagonists is described. The new compounds are high affinity histamine H3 ligands that penetrate the CNS and occupy the histamine H3 receptor in rat brain.

2-Aryloxymethylmorpholines are potent histamine H3 antagonists.Figure optionsDownload as PowerPoint slide