Keywords: هیستامین H3 گیرنده; α-CGRP; alpha-calcitonin gene related peptide; Ang; angiopoietin; AE2; anion exchanger 2; ADP; adenosine diphosphate; ADPKD; autosomal dominant polycystic kidney disease; ATP; adenosine triphosphate; ASBT; sodium-dependent bile acid transporter; AQP; aqu
مقالات ISI هیستامین H3 گیرنده (ترجمه نشده)
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Keywords: هیستامین H3 گیرنده; Histamine H3 receptor; Steroid; Estrane derivatives; Antagonist/inverse agonist; Dipsogenia model;
Keywords: هیستامین H3 گیرنده; Acetylcholinesterase inhibitors; Butyrylcholinesterase inhibitors; Histamine H3 receptor; Multifunctional ligands; Chlorophenoxy derivatives
Keywords: هیستامین H3 گیرنده; Drug design; 3D-QSAR; Histamine H3 receptor; Histamine N-methyltransferase; Pharmacophore; Virtual screening;
Keywords: هیستامین H3 گیرنده; VKZMICHNLVMXRJ-UAPYVXQJSA-N; Histamine; Histamine H3 receptor; Pharmacophore; Half-life; Pharmacokinetics;
Keywords: هیستامین H3 گیرنده; Addiction; Memory; Cognition; Histamine; Histamine H3 receptor; Acetylcholine;
Keywords: هیستامین H3 گیرنده; [11C]TASP457; Histamine H3 receptor; PET; 2-Hydroxypyridine; Quality control
New lead elements for histamine H3 receptor ligands in the pyrrolo[2,3-d]pyrimidine class
Keywords: هیستامین H3 گیرنده; Histamine H3 receptor; Pyrrolo[2,3-d]pyrimidine derivatives; Microwave assisted synthesis; G-protein coupled receptors;
Synthesis and biological activity of novel tert-butyl and tert-pentylphenoxyalkyl piperazine derivatives as histamine H3R ligands
Keywords: هیستامین H3 گیرنده; Histamine H3 receptor; Histamine H3 receptor ligands; Non-imidazole histamine H3R ligands; Piperazine derivatives; Anticonvulsants; Pro-cognitives; Molecular docking; Metabolic stability; QOXOVGLCVCFFFR-UHFFFAOYSA-N; DWCLOFJVHUBMBQ-UHFFFAOYSA-N; AXSBUUREH
Functional histamine H3 and adenosine A2A receptor heteromers in recombinant cells and rat striatum
Keywords: هیستامین H3 گیرنده; A2AR; Adenosine A2A receptor; cAMP; Cyclic adenosine monophosphate; D1R; Dopamine D1 receptor; D2R; Dopamine D2 receptor; dMSNs; Direct pathway striatal medium-sized spiny neurons; GABA; γ-Aminobutyric acid; GPCRs; G-protein coupled receptors; H2R; Hista
The naturally occurring mutation Y197C does not affect the expression or signaling of the human histamine H3 receptor
Keywords: هیستامین H3 گیرنده; GPCR; G protein-coupled receptor; H3R; histamine H3 receptor; hH3R; human histamine H3 receptor; RAMH; (R)-α-methylhistamine; TM; transmembrane domain; Histamine; H3 receptor; Mutation; Y197C mutation; Signaling; CHO-K1 cells;
JNJ10181457, a histamine H3 receptor inverse agonist, regulates in vivo microglial functions and improves depression-like behaviours in mice
Keywords: هیستامین H3 گیرنده; Histamine; Histamine H3 receptor; Microglia; Depression;
Time-dependent effects of olanzapine treatment on the expression of histidine decarboxylase, H1 and H3 receptor in the rat brain: The roles in olanzapine-induced obesity
Keywords: هیستامین H3 گیرنده; Antipsychotics; Olanzapine; Histidine decarboxylase; Histamine H1 receptor; Histamine H3 receptor; Weight gain;
Synthesis and biological activity of novel tert-amylphenoxyalkyl (homo)piperidine derivatives as histamine H3R ligands
Keywords: هیستامین H3 گیرنده; Histamine H3 receptor; Histamine H3 receptor ligands; Non-imidazole histamine H3R ligands; Piperidine derivatives; Anticonvulsants; Molecular docking; Drug-like properties; NLVYWCRLGFDESU-UHFFFAOYSA-N; CUKJWVHEMLBESD-UHFFFAOYSA-N; POQQPNLUXGVXQL-UHFFFAOYS
A search for presynaptic inhibitory histamine receptors in guinea-pig tissues: Further H3 receptors but no evidence for H4 receptors
Keywords: هیستامین H3 گیرنده; Histamine H4 receptor; Histamine H3 receptor; Guinea-pig atrium; Presynaptic receptor; Noradrenaline release; Acetylcholine release;
Benzamide derivatives and their constrained analogs as histamine H3 receptor antagonists
Keywords: هیستامین H3 گیرنده; Histamine H3 receptor; SAR; Pharmacokinetic profile; Receptor occupancy;
The dual-acting AChE inhibitor and H3 receptor antagonist UW-MD-72 reverses amnesia induced by scopolamine or dizocilpine in passive avoidance paradigm in rats
Keywords: هیستامین H3 گیرنده; AChE; acetylcholine esterase; BChE; butyrylcholinesterase; AChEI; acetylcholine esterase inhibitor; H3R; histamine H3 receptor; H1R; histamine H1 receptor; H2R; histamine H2 receptor; AD; Alzheimer's disease; SCO; scopolamine; NMDA; N-methyl-d-aspartate;
3-(1â²-Cyclobutylspiro[4H-1,3-benzodioxine-2,4â²-piperidine]-6-yl)-5,5-dimethyl-1,4-dihydropyridazin-6-one (CEP-32215), a new wake-promoting histamine H3 antagonist/inverse agonist
Keywords: هیستامین H3 گیرنده; Histamine H3 receptor; H3R inverse agonist; CEP-32215; Sleep wake activity; CEP-32215; 3-(1â²-cyclobutylspiro[4H-1,3-benzodioxine-2,4â²-piperidine]-6-yl)-5,5-dimethyl-1,4-dihydropyridazin-6-one hydrochloride; EDS; excessive daytime sleepiness; EEG; elec
Research reportThe dual-acting H3 receptor antagonist and AChE inhibitor UW-MD-71 dose-dependently enhances memory retrieval and reverses dizocilpine-induced memory impairment in rats
Keywords: هیستامین H3 گیرنده; Histamine H3 receptor; Acetylcholinesterase; Dual-acting ligand; Learning; Memory; Inhibitory avoidance test; Pyrilamine; Zolantidine.;
Anticonvulsant and procognitive properties of the non-imidazole histamine H3 receptor antagonist DL77 in male adult rats
Keywords: هیستامین H3 گیرنده; Histamine H3 receptor; Epilepsy; Anticonvulsant; Learning; Memory; Passive avoidance test; Pyrilamine; R-(α)-methyl-histamine; H3Rs; histamine H3 receptors; MES; maximal electroshock; PTZ; pentylenetetrazole; STR; strychnine; AED; antiepileptic drug; PHT
Histamine H3 receptor activation inhibits dopamine synthesis but not release or uptake in rat nucleus accumbens
Keywords: هیستامین H3 گیرنده; Histamine; Dopamine; H3 receptor; Nucleus accumbens; Dopamine synthesis; Dopamine release; D2R; dopamine D2 receptor; DOPA; l-dihydroxyphenylalanine; GABA; γ-aminobutyric acid; H3R; histamine H3 receptor; MSNs; medium spiny neurons; RAMH; (R)(-)-α-methy
Action of Pitolisant on the stimulant and rewarding effects of cocaine in mice
Keywords: هیستامین H3 گیرنده; Pitolisant; Cocaine; Histamine H3 receptor; Conditioned place preference; Reward; Locomotion;
Donepezil, an acetylcholine esterase inhibitor, and ABT-239, a histamine H3 receptor antagonist/inverse agonist, require the integrity of brain histamine system to exert biochemical and procognitive effects in the mouse
Keywords: هیستامین H3 گیرنده; HDC-KO mice; a-fluoromethylhistidine; Object recognition test; Memory; Acetylcholine; GSK-3β; a-FMHis; alpha-fluromethylhistidine; H3R; histamine H3 receptor; HDC; histidine decarboxylase; ORT; object recognition test; T1; training session; T2; test sess
Histamine H3 receptor activation stimulates calcium mobilization in a subpopulation of rat striatal neurons in primary culture, but not in synaptosomes
Keywords: هیستامین H3 گیرنده; Histamine; H3 receptor; Striatum; Calcium mobilization; Primary culture; Synaptosomes; ACPD; (±)-trans 1-Amino-1,3-dicarboxycyclopentane; [Ca2+]i; intracellular concentration of Ca2+; CNS; Central Nervous System; D1R; dopamine D1 receptor; D2R; dopamine
Molecular and cellular pharmacologyActivation of histamine H3 receptor decreased cytoplasmic Ca2+ imaging during electrical stimulation in the skeletal myotubes
Keywords: هیستامین H3 گیرنده; Skeletal myogenesis; Histamine H3 receptor; Calcium; Skeletal myotubes; Electrical stimulation;
3,4-Diaza-bicyclo[4.1.0]hept-4-en-2-one phenoxypropylamine analogs of irdabisant (CEP-26401) as potent histamine-3 receptor inverse agonists with robust wake-promoting activity
Keywords: هیستامین H3 گیرنده; Histamine H3 receptor; H3 inverse agonist; Irdabisant; CEP-26401; Pyridazin-3-one; Sleep-wake;
The novel non-imidazole histamine H3 receptor antagonist DL77 reduces voluntary alcohol intake and ethanol-induced conditioned place preference in mice
Keywords: هیستامین H3 گیرنده; BEC; blood ethanol concentration; CPP; conditioned-place preference; EtOH; ethanol; H3R; histamine H3 receptor; PYR; pyrilamine; RAMH; R-(alpha)-methyl-histamine; Conditioned place preference; Ethanol; Histamine H3 receptor; Pyrilamine; R-(alpha)-methyl-h
Benzylpiperidine variations on histamine H3 receptor ligands for improved drug-likeness
Keywords: هیستامین H3 گیرنده; GPCR; Histamine H3 receptor; Antagonists; Drug-likeness; Lipophilicity
Discovery of (1R,6S)-5-[4-(1-cyclobutyl-piperidin-4-yloxy)-phenyl]-3,4-diaza-bicyclo[4.1.0]hept-4-en-2-one (R,S-4a): Histamine H3 receptor inverse agonist demonstrating potent cognitive enhancing and wake promoting activity
Keywords: هیستامین H3 گیرنده; Histamine H3 receptor; H3 inverse agonist; CEP-26401; Pyridazin-3-one; Sleep–wake; Cognition
Homologous desensitization of human histamine H3 receptors expressed in CHO-K1 cells
Keywords: هیستامین H3 گیرنده; Histamine; H3 receptor; Desensitization; GRK; CHO-K1 cells; Neuromodulation; H3R; histamine H3 receptor; GPCR; G protein-coupled receptor; GRK; GPCR kinase; RAMH; R-α-methylhistamine;
Studies on molecular properties prediction and histamine H3 receptor affinities of novel ligands with uracil-based motifs
Keywords: هیستامین H3 گیرنده; GPCR; Histamine H3 receptor; Antagonists; Pyrimidine-2,4-(1H,3H)-dione; Drug-likeness
Selective brain region activation by histamine H3 receptor antagonist/inverse agonist ABT-239 enhances acetylcholine and histamine release and increases c-Fos expression
Keywords: هیستامین H3 گیرنده; Acetylcholine; c-Fos; Histamine; Histamine H3 receptor; Microdialysis; H3R; histamine H3 receptor; ACh; acetylcholine; ADHD; attention-deficit hyperactivity disorder; i.p.; intraperitoneally; PBS; phosphate-buffer saline; TMN; tuberomamillary nucleus; NBM
Discovery of aryl ureas and aryl amides as potent and selective histamine H3 receptor antagonists for the treatment of obesity (Part I)
Keywords: هیستامین H3 گیرنده; Histamine H3 receptor; Antagonist/inverse agonist; Obesity; Aryl urea
Discovery of aryl ureas and aryl amides as potent and selective histamine H3 receptor antagonists for the treatment of obesity (Part II)
Keywords: هیستامین H3 گیرنده; Histamine H3 receptor; Antagonist/inverse agonist; Obesity; Aryl amide
Identification and pharmacological characterization of the histamine H3 receptor in cultured rat astrocytes
Keywords: هیستامین H3 گیرنده; Histamine; Histamine H3 receptor; Immunofluorescence; [3H]N-α-methylhistamine binding; Astrocytes; Rat
Substituted phenoxypropyl-(R)-2-methylpyrrolidine aminomethyl ketones as histamine-3 receptor inverse agonists
Keywords: هیستامین H3 گیرنده; Phenoxypropyl-(R)-2-methylpyrrolidine; CEP-26401 irdabisant; Histamine H3 receptor; Inverse agonist; Sleep-wake
Awakening properties of newly discovered highly selective H3 receptor antagonists in rats
Keywords: هیستامین H3 گیرنده; Histamine H3 receptor; Awakening; EEG; Rats
4,5-Dihydropyridazin-3-one derivatives as histamine H3 receptor inverse agonists
Keywords: هیستامین H3 گیرنده; Histamine H3 receptor; H3 inverse agonist; CEP-26401; 4,5-Dihydropyridazin-3-one; Sleep-wake;
Synthesis and structure-activity relationship of 5-pyridazin-3-one phenoxypiperidines as potent, selective histamine H3 receptor inverse agonists
Keywords: هیستامین H3 گیرنده; Phenoxypiperidine; 5-pyridazin-3-one; Histamine H3 receptor; CEP-26401 irdabisant; Sleep-wake;
4-Phenoxypiperidine pyridazin-3-one histamine H3 receptor inverse agonists demonstrating potent and robust wake promoting activity
Keywords: هیستامین H3 گیرنده; Histamine H3 receptor; H3 inverse agonist; Pyridazin-3-one; CEP-26401; Irdabisant; Sleep–wake
A new facile synthetic route to [11C]GSK189254, a selective PET radioligand for imaging of CNS histamine H3 receptor
Keywords: هیستامین H3 گیرنده; [11C]GSK189254; Histamine H3 receptor; Radiosynthesis; Automation; Positron emission tomography (PET); Brain imaging
Ligand based design of novel histamine H4 receptor antagonists; fragment optimization and analysis of binding kinetics
Keywords: هیستامین H3 گیرنده; Histamine; H4R antagonist; GPCR; Binding kinetics; Fragment optimization; GPCRs; G protein-coupled receptors; H1R; histamine H1 receptor; H2R; histamine H2 receptor; H3R; histamine H3 receptor; H4R; histamine H4 receptor; SAR; structure-activity relatio
Novel sulfonylurea derivatives as H3 receptor antagonists. Preliminary SAR studies
Keywords: هیستامین H3 گیرنده; Histamine H3 receptor; Obesity; Sulfonylurea; Type 2 diabetes mellitusN.T., Not Tested; SEM, standard error of the media
Dibasic biphenyl H3 receptor antagonists: Steric tolerance for a lipophilic side chain
Keywords: هیستامین H3 گیرنده; Histamine H3 receptor; H3-antagonist; NMR analysis
Novel and highly potent histamine H3 receptor ligands. Part 2: Exploring the cyclohexylamine-based series
Keywords: هیستامین H3 گیرنده; Histamine; Histamine H3 receptor; GPCR; hERG;
Pulmonary, Gastrointestinal and Urogenital PharmacologySelective histamine H3 and H4 receptor agonists exert opposite effects against the gastric lesions induced by HCl in the rat stomach
Keywords: هیستامین H3 گیرنده; Histamine H3 receptor; Histamine H4 receptor; Binding; Gastric lesions; HCl;
In-vivo histamine H3 receptor antagonism activates cellular signaling suggestive of symptomatic and disease modifying efficacy in Alzheimer's disease
Keywords: هیستامین H3 گیرنده; Histamine H3 receptor; Antagonist; CREB; S9-GSK3β; Tau; Phosphorylation;
Histamine H3 receptor-mediated modulation of perivascular nerve transmission in rat mesenteric arteries
Keywords: هیستامین H3 گیرنده; Histamine H3 receptor; Neurotransmission; Periarterial nerve stimulation; Noradrenaline; Calcitonin gene-related peptide; Rat mesenteric artery
The hydrophobic amino acids in putative helix 8 in carboxy-terminus of histamine H3 receptor are involved in receptor-G-protein coupling
Keywords: هیستامین H3 گیرنده; GPCR; G-protein coupled receptor; H3R; histamine H3 receptor; HEK; human embryonic kidney; CLIC4; chloride intracellular channel 4; DMEM; Dulbecco's modified Eagle's medium; PBS; phosphate buffered saline; PAGE; polyacrylamide gel electrophoresis; RAMH; R
Involvement of histaminergic receptor mechanisms in the stimulation of NT-3 synthesis in astrocytes
Keywords: هیستامین H3 گیرنده; Histamine; Histamine receptor; Histamine H3 receptor; Neurotrophin-3; Astrocytes; Rat