3-Hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxylates—A new class of HIV-1 integrase inhibitors

A new class of inhibitors of HIV-1 integrase has been optimized to provide selective and highly efficient strand transfer inhibition.

The synthesis and SAR of a new class of HIV-1 integrase inhibitors is reported.Figure optionsDownload as PowerPoint slide