Adjuvant properties of a simplified C32 monomycolyl glycerol analogue

A simplified C32 monomycolyl glycerol (MMG) analogue demonstrated enhanced immunostimulatory activity in a dioctadecyl ammonium bromide (DDA)/Ag85B-ESAT-6 formulation. Elevated levels of IFN-γ and IL-6 were produced in spleen cells from mice immunised with a C32 MMG analogue comparable activity to the potent Th1 adjuvant, trehalose 6,6′-di-behenate (TDB).

A C32 monomycolyl glycerol analogue demonstrated elevated INF-γ and IL-6 levels, comparable to that of the potent Th1 adjuvant trehalose 6,6′ di-behenate (TBD) in a dioctadecyl ammonium bromide (DDA)/Ag85B-ESAT-6 formulation.Figure optionsDownload as PowerPoint slide