کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1375346 981937 2010 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Proposed structural basis of interaction of piperine and related compounds with monoamine oxidases
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Proposed structural basis of interaction of piperine and related compounds with monoamine oxidases
چکیده انگلیسی

Several studies have revealed piperine and a few related compounds as potent inhibitors of monoamine oxidases without delineating the underlying mechanism. Using in silico modelling, we propose a structural basis of such activity by showing that these compounds can successfully dock into the inhibitor binding pockets of human monoamine oxidase isoforms with predicted affinities comparable to some known inhibitors. The results therefore suggest that piperine can be a promising lead for developing novel monoamine oxidase inhibitors.

The putative molecular interaction of piperine and related compounds with human monoamine oxidases is assessed using computational docking.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 20, Issue 2, 15 January 2010, Pages 537–540
نویسندگان
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