کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1375419 | 981938 | 2008 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Possible chemical mechanisms underlying the antitumor activity of S-deoxyleinamycin Possible chemical mechanisms underlying the antitumor activity of S-deoxyleinamycin](/preview/png/1375419.png)
Though less potent than the parent natural product leinamycin, S-deoxyleinamycin displays activity against human cancer cell lines that is comparable to many clinically used agents. The results reported here suggest that the 1,2-dithiolan-3-one heterocycle found in S-deoxyleinamycin reacts with thiols to generate a persulfide intermediate (RSS−) that could deliver biologically active polysulfides, hydrogen sulfide, and reactive oxygen species (O2-, H2O2, and HO) to the interior of cells.
Though less potent than the parent natural product leinamycin, S-deoxyleinamycin displays activity against human cancer cell lines that is comparable to many clinically used agents. The 1,2-dithiolan-3-one heterocycle found in S-deoxyleinamycin may react with thiols to generate a persulfide intermediate (RSS−) that delivers biologically active polysulfides, hydrogen sulfide, and reactive oxygen species (O2-, H2O2, and HO) to the interior of cells.Figure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 10, 15 May 2008, Pages 3076–3080