Estrogen receptor β selective ligands: Discovery and SAR of novel heterocyclic ligands

A series of ligands with varying heterocyclic cores and substituents that display a range of selectivity’s (up to >100x) for ER-β over ER-α are reported.

A series of ligands with varying heterocyclic cores and substituents that display a range of selectivities (up to >100×) for ER-β over ER-α are reported.Figure optionsDownload as PowerPoint slide