کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1375583 981941 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Molecular hybridization, synthesis, and biological evaluation of novel chroman IKr and IKs dual blockers
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Molecular hybridization, synthesis, and biological evaluation of novel chroman IKr and IKs dual blockers
چکیده انگلیسی

The combination of IKr and IKs blockade could lead to synergistic and safe class III anti-arrhythmic effect with the enhanced efficacy and reduced risk. On the rationale of structural hybridization of azimilide and HMR-1556, a novel series of IKr and IKs dual blockers were designed, synthesized and evaluated in vitro. One compound, 3r (CPUY11018), deserves further evaluation for its potent anti-arrhythmic activity and favorable cardiovascular profile.

On the rationale of molecular hybridization of azimilide and HMR-1556, a novel series of IKr and IKs dual blockers were designed, synthesized and evaluated.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 19, Issue 5, 1 March 2009, Pages 1477–1480
نویسندگان
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