Alkyne–quinuclidine derivatives as potent and selective muscarinic antagonists for the treatment of COPD

SAR around alkyne–quinuclidine derivatives allowed the discovery of highly potent muscarinic antagonists displaying interesting preferential slow off-rates from the M3 receptor.

SAR around alkyne–quinuclidine derivatives allowed the discovery of highly potent muscarinic antagonists displaying interesting preferential slow off-rates from the M3 receptor.Figure optionsDownload as PowerPoint slide