کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1375839 981946 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and structure–activity relationships of 2-phenyl-1-[(pyridinyl- and piperidinylmethyl)amino]-3-(1H-1,2,4-triazol-1-yl)propan-2-ols as antifungal agents
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis and structure–activity relationships of 2-phenyl-1-[(pyridinyl- and piperidinylmethyl)amino]-3-(1H-1,2,4-triazol-1-yl)propan-2-ols as antifungal agents
چکیده انگلیسی

Continuous efforts on the synthesis and structure–activity relationships (SARs) studies of modified 1-benzylamino-2-phenyl-3-(1H-1,2,4-triazol-1-yl)propan-2-ols as antifungal agents, allowed identification of new 1-[(pyridinyl- and piperidinylmethyl)amino] derivatives with MIC80 values ranging from 1410.0 to 23.0 ng mL−1 on Candidaalbicans. These results confirmed both the importance of π–π stacking and hydrogen bonding interactions in the active site of CYP51-C. albicans.

Synthesis and SAR studies of modified 1-benzylamino-2-phenyl-3-(1H-1,2,4-triazol-1yl)propan-2-ols as antifungal agents, allowed identification of new derivatives with MIC80 values ranging from 1410.0 to 23.0 ng mL−1 on the Candidaalbicans strain.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 19, Issue 2, 15 January 2009, Pages 301–304
نویسندگان
, , , , , , ,