کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1375881 | 981946 | 2009 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Tethered indoles as functionalizable ligands for the estrogen receptor
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Tethered indoles as functionalizable ligands for the estrogen receptor Tethered indoles as functionalizable ligands for the estrogen receptor](/preview/png/1375881.png)
چکیده انگلیسی
To create ligands for the estrogen receptor that contain pendant groups for tethering to a poly(amido)amine (PAMAM) dendrimer, we have explored a class of N-substituted 2-phenyl indoles. Attachment of tethers of different length and chemical nature to this non-steroidal indole scaffold gave high affinity ligand-tether conjugates that can be easily functionalized. To further explore the utility of this system, an indole-conjugated dendrimer was prepared and evaluated as an estrogen receptor ligand.
We report the synthesis of N-substituted-2-phenylindoles as estrogen receptor ligands. Optimal tether lengths were explored for creating a PAMAM-conjugated indole ligand.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 19, Issue 2, 15 January 2009, Pages 485–488
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 19, Issue 2, 15 January 2009, Pages 485–488
نویسندگان
Bridget G. Trogden, Sung Hoon Kim, Shuyi Lee, John A. Katzenellenbogen,