کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1375923 981947 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Design, synthesis, and biological evaluation of biotin-labeled (−)-ternatin, a potent fat-accumulation inhibitor against 3T3-L1 adipocytes
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Design, synthesis, and biological evaluation of biotin-labeled (−)-ternatin, a potent fat-accumulation inhibitor against 3T3-L1 adipocytes
چکیده انگلیسی

The design, synthesis, and biological activity of biotin-labeled (−)-ternatin are reported. Chemical modification, that is, biotinylation, was conducted using Click chemistry at the 6-position (NMe-d-ProGly moiety), which was a plausible location selected on the basis of our SAR studies. The compound displayed sufficient fat-accumulation inhibitory effect against 3T3-L1 adipocytes for further bio-organic studies.

Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 19, Issue 1, 1 January 2009, Pages 92–95
نویسندگان
, , , , ,