کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1375930 981947 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Sulfonamido-aryl ethers as bradykinin B1 receptor antagonists
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Sulfonamido-aryl ethers as bradykinin B1 receptor antagonists
چکیده انگلیسی

The synthesis and identification of sulfonamido-aryl ethers as potent bradykinin B1 receptor antagonists from a ∼60,000 member encoded combinatorial library are reported. Two distinct series of compounds exhibiting different structure–activity relationships were identified in a bradykinin B1 whole-cell receptor-binding assay. Specific examples exhibit Ki values of ∼10 nM.

Two distinct series of sulfonamido-aryl ethers as potent bradykinin B1 receptor antagonists consistent with a proposed B1 antagonist pharmacophore are reported.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 19, Issue 1, 1 January 2009, Pages 119–122
نویسندگان
, , , , , , , , , , , , , ,