Two new cytotoxic diterpenes from the rhizomes of Hedychium spicatum

Phytochemical investigation of CHCl3 extract of the rhizomes of Hedychium spicatum led to the isolation of two new labdane-type diterpenes, compounds 1 and 2 along with five known compounds (3–7). Their structures were established on the basis of NMR (1D and 2D) and mass spectroscopic analysis. In addition, all the isolates were tested for their cytotoxicity against the Colo-205 (Colo-cancer), A-431 (skin cancer), MCF-7 (breast cancer), A-549 (lung cancer) and Chinese hamster ovary cells (CHO). Two new compounds 1 and 2 were shown good cytotoxic activity.

Phytochemical investigation of the rhizomes of the Hedychium spicatum yielded two new compounds (1 and 2) along with known compounds (3–7). Anticancer activity of the isolates were studied on colon cancer (Colo-205), skin cancer (A-431), breast cancer (MCF-7), lung cancer (A-549) and Chinese hamster ovary cells (CHO cell lines).Figure optionsDownload as PowerPoint slide