Pyridine-3-carboxamides as novel CB2 agonists for analgesia

We describe herein the medicinal chemistry approach which led to the discovery of a novel pyridine-3-carboxamide series of CB2 receptor agonists. The SAR of this new template was evaluated and culminated in the identification of analogue 14a which demonstrated efficacy in an in vivo model of inflammatory pain.

The synthesis and biological profile of the pyridine-3-carboxamide 14a and related analogues are described.Figure optionsDownload as PowerPoint slide