کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1376050 | 981949 | 2007 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Design and synthesis of indane-ureido-thioisobutyric acids: A novel class of PPARα agonists
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
A series of aminoindane derivatives were synthesized and shown to be potent PPARα agonists. The compounds were obtained as racemates in 12 steps, and tested for PPARα activation and PPARα mediated induction of the HD gene. SAR was developed by variation to the core structure as shown within. Oral bioavailability was demonstrated in a Sprague–Dawley rat, while efficacy to reduce plasma triglycerides and plasma glucose was demonstrated in db/db mice.
The synthesis and SAR of novel, highly potent PPARα agonists based on an indane scaffold are reported.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 24, 15 December 2007, Pages 6773–6778
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 24, 15 December 2007, Pages 6773–6778
نویسندگان
Jay M. Matthews, Xiaoli Chen, Ellen Cryan, Dennis J. Hlasta, Philip J. Rybczynski, Kim Strauss, Yuting Tang, June Z. Xu, Maria Yang, Lubing Zhou, Keith T. Demarest,