Structure–activity relationship studies of the chromosome segregation inhibitor, Incentrom A

A series of Incentrom A analogs that inhibit the chromosome segregation process in yeast were synthesized and tested for their effects on chromosome stability and cell proliferation. Pharmacophore and structure–activity relationship of Incentrom A for the anti-yeast activity were established.

Pharmacophore and structure–activity relationship of Incentrom A that inhibits the chromosome segregation process in yeast were established. A series of Incentrom A analogs were synthesized and tested for the anti-yeast activity.Figure optionsDownload as PowerPoint slide