کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1376315 | 981954 | 2007 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis of novel diaryl ethers and their evaluation as antimitotic agents
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Synthesis of novel diaryl ethers and their evaluation as antimitotic agents Synthesis of novel diaryl ethers and their evaluation as antimitotic agents](/preview/png/1376315.png)
چکیده انگلیسی
A series of novel diaryl ethers possessing various functional groups were synthesized and evaluated for antiproliferative activity in human myeloid leukemia HL-60 cells. Among the compounds examined, compounds 10, 17, 20, 24, and 33 showed moderate to potent antiproliferative activity. These derivatives were further examined in terms of their abilities to inhibit tubulin polymerization; however, all of the tested compounds were relatively ineffective. The reference compound E7010 with an IC50 of 0.34 μM exhibited potent antiproliferative activity and significantly inhibited tubulin polymerization in a dose-dependent manner.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 6, 15 March 2007, Pages 1799–1802
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 6, 15 March 2007, Pages 1799–1802
نویسندگان
Jin-Kyung In, Mi-Sung Lee, Jung-Eun Yang, Jae-Hwan Kwak, Heesoon Lee, Shanthaveerappa K. Boovanahalli, Kyeong Lee, Soo Jin Kim, Seung Kee Moon, Sungsook Lee, Nam Song Choi, Soon Kil Ahn, Jae-Kyung Jung,