C3-Spacer-containing circular oligonucleotides as inhibitors of human topoisomerase I

Some dumbbell-shaped circular oligonucleotides containing internal C3-spacers and Topo I-binding sites were designed and synthesized which displayed high inhibitory efficiency on the activity of human Topo I as well as resisted the degradation by some DNA repair enzymes.

Some dumbbell-shaped circular oligonucleotides containing C3-spacer modifications and Topo I-binding sites were synthesized which displayed high inhibitory efficiency on the activity of human Topo I as well as resisted the degradation by certain DNA repair enzyme.Figure optionsDownload as PowerPoint slide