کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1376386 981957 2008 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Molecular modeling of a PAMAM-CGS21680 dendrimer bound to an A2A adenosine receptor homodimer
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Molecular modeling of a PAMAM-CGS21680 dendrimer bound to an A2A adenosine receptor homodimer
چکیده انگلیسی
The theoretical possibility of bivalent binding of a dendrimer, covalently appended with multiple copies of a small ligand, to a homodimer of a G protein-coupled receptor was investigated with a molecular modeling approach. A molecular model was constructed of a third generation (G3) poly(amidoamine) (PAMAM) dendrimer condensed with multiple copies of the potent A2A adenosine receptor agonist CGS21680. The dendrimer was bound to an A2A adenosine receptor homodimer. Two units of the nucleoside CGS21680 could occupy the A2A receptor homodimer simultaneously. The binding mode of CGS21680 moieties linked to the PAMAM dendrimer and docked to the A2A receptor was found to be similar to the binding mode of a monomeric CGS21680 ligand.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 15, 1 August 2008, Pages 4312-4315
نویسندگان
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