کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1376483 | 981959 | 2006 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Synthesis and in vitro pharmacological studies of new C(4)-modified salvinorin A analogues Synthesis and in vitro pharmacological studies of new C(4)-modified salvinorin A analogues](/preview/png/1376483.png)
Salvinorin A, a compound isolated from the plant Salvia divinorum, is a potent and highly selective agonist for the κ opioid receptor. For exploration of its structure and activity relationships, further modifications, such as reduction at the C(4) position, have been studied and a series of salvinorin A derivatives were prepared. These C(4)-modified salvinorin A analogues were screened for binding and functional activities at the human κ-opioid receptor and several new full agonists have been identified.
A series of salvinorin A derivatives modified at the C(4) position were prepared and screened for binding and functional activities at the human κ-opioid receptor. Several selective κ-full agonists are reported.Figure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 21, 1 November 2006, Pages 5498–5502