کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1376494 981959 2006 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Discovery and preliminary structure–activity relationship studies of novel benzotriazine based compounds as Src inhibitors
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Discovery and preliminary structure–activity relationship studies of novel benzotriazine based compounds as Src inhibitors
چکیده انگلیسی

We report the discovery and preliminary SAR studies of a series of structurally novel benzotriazine core based small molecules as inhibitors of Src kinase. To the best of our knowledge, benzotriazine template based compounds have not been reported as kinase inhibitors. The 3-(2-(1-pyrrolidinyl)ethoxy)phenyl analogue (43) was identified as one of the most potent inhibitors of Src kinase.

We report the SAR studies of a series of structurally novel benzotriazine analogs as inhibitors of Src. The 3-(2-(1-pyrrolidinyl)-ethoxy)phenyl analog (43) was identified as one of the most potent inhibitors.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 21, 1 November 2006, Pages 5546–5550
نویسندگان
, , , , , , , , , , , , , , , , ,