کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1376494 | 981959 | 2006 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Discovery and preliminary structure–activity relationship studies of novel benzotriazine based compounds as Src inhibitors
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
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چکیده انگلیسی
We report the discovery and preliminary SAR studies of a series of structurally novel benzotriazine core based small molecules as inhibitors of Src kinase. To the best of our knowledge, benzotriazine template based compounds have not been reported as kinase inhibitors. The 3-(2-(1-pyrrolidinyl)ethoxy)phenyl analogue (43) was identified as one of the most potent inhibitors of Src kinase.
We report the SAR studies of a series of structurally novel benzotriazine analogs as inhibitors of Src. The 3-(2-(1-pyrrolidinyl)-ethoxy)phenyl analog (43) was identified as one of the most potent inhibitors.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 21, 1 November 2006, Pages 5546–5550
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 21, 1 November 2006, Pages 5546–5550
نویسندگان
Glenn Noronha, Kathy Barrett, Jianguo Cao, Elena Dneprovskaia, Richard Fine, Xianchang Gong, Colleen Gritzen, John Hood, Xinshan Kang, Boris Klebansky, G. Li, W. Liao, Dan Lohse, Chi Ching Mak, Andrew McPherson, Moorthy S.S. Palanki, Ved P. Pathak,