کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1376504 981959 2006 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A homology model of SERT based on the LeuTAa template
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
A homology model of SERT based on the LeuTAa template
چکیده انگلیسی

A human serotonin transporter (SERT) model has been constructed based on the crystal structure of the bacterial homologue of Na+/Cl−-dependent neurotransmitter transporters from Aquifex aeolicus (LeuTAa). Amino acids in the ligand binding area predicted by ICM pocket finder included Tyr95, Ala96, Asp98, Gly100 (transmembrane helix (TMH) 1), Ala169, Ile172, Ala173, Tyr176 (TMH3), Phe335, Ser336, Gly338, Phe341, Val343 (TMH6), Thr439, Ala441, and Gly442 (TMH8). The present model is an updated working tool for experimental studies on SERT.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 21, 1 November 2006, Pages 5594–5597
نویسندگان
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