کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1376566 | 981961 | 2008 | 4 صفحه PDF | دانلود رایگان |
We describe herein the discovery and development of a series of 4-arylthieno[3,2-d]pyrimidines which are potent adenosine A2A receptor antagonists. These novel compounds show high degrees of selectivity against the human A1, A2B and A3 receptor sub-types. Moreover, a number of these compounds show promising activity in vivo, suggesting potential utility in the treatment of Parkinson’s disease.
The design and synthesis of a series of biaryl thieno[3,2-d]pyrimidines is described. These novel compounds are potent adenosine A2A receptor antagonists and show high degrees of selectivity against human A1, A2B and A3 receptors. Moreover, a number of these compounds show promising activity in in vivo models of Parkinson’s disease.Figure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 9, 1 May 2008, Pages 2920–2923