New targeting system for antimycotic drugs: β-Glucosidase sensitive Amphotericin B–star poly(ethylene glycol) conjugate

A new targeting potentially intravenous conjugate Amphotericin B (AMB)–star poly(ethylene glycol) (sPEG) (M = 25,160) has been synthesized and characterized. It contains a β-d-glucopyranoside molecular switch which is sensitive to β-glucosidases (E.C.3.2.1.21). The β-glucosidase-catalyzed release of AMB from the polymeric carrier was proved in vitro by means of spectrophotometry and HPLC.

The prepared conjugate of Amphotericin B with star poly(ethylene glycol) represent a new targeting system which is sensitive to β-glucosidases (E.C.3.2.1.21).Figure optionsDownload as PowerPoint slide