کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1376573 981961 2008 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
New targeting system for antimycotic drugs: β-Glucosidase sensitive Amphotericin B–star poly(ethylene glycol) conjugate
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
New targeting system for antimycotic drugs: β-Glucosidase sensitive Amphotericin B–star poly(ethylene glycol) conjugate
چکیده انگلیسی

A new targeting potentially intravenous conjugate Amphotericin B (AMB)–star poly(ethylene glycol) (sPEG) (M = 25,160) has been synthesized and characterized. It contains a β-d-glucopyranoside molecular switch which is sensitive to β-glucosidases (E.C.3.2.1.21). The β-glucosidase-catalyzed release of AMB from the polymeric carrier was proved in vitro by means of spectrophotometry and HPLC.

The prepared conjugate of Amphotericin B with star poly(ethylene glycol) represent a new targeting system which is sensitive to β-glucosidases (E.C.3.2.1.21).Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 9, 1 May 2008, Pages 2952–2956
نویسندگان
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