کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1376755 | 981964 | 2006 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Evaluation of antitumor properties of novel saframycin analogs in vitro and in vivo
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Novel analogs of (−)-saframycin A are described. The analogs are shown to be potent inhibitors of the in vitro growth of several tumor cells in a broad panel and promising as leads for further optimization. The first in vivo studies in a solid tumor model (HCT-116) reveal potent antitumor activity with associated toxicity of daily administration.
Novel analogs of (−)-saframycin A are described. Analogs are shown to be potent inhibitors of the in vitro growth of several tumor cells and active antitumor agents in a solid tumor model (HCT-116).Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 18, 15 September 2006, Pages 4884–4888
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 18, 15 September 2006, Pages 4884–4888
نویسندگان
Jeffrey R. Spencer, Martin Sendzik, Jason Oeh, Peter Sabbatini, Stacie A. Dalrymple, Catherine Magill, Hyunjin M. Kim, Penglie Zhang, Neil Squires, Katherine G. Moss, Juthamas Sukbuntherng, Doris Graupe, John Eksterowicz, Peter R. Young, Andrew G. Myers,