Keywords: Steroids; Oxazoline; Oxazolidine; Heterocycles; Antiproliferative activity; COSY; Correlation Spectroscopy; DEPT; Distortionless Enhancement by Polarization Transfer; EI; Electronic Impact; ESI; ElectroSpray Ionization; FAB; Fast Atom Bombardment; FDA; Fo
مقالات ISI (ترجمه نشده)
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Keywords: GI50; half-maximal cell growth inhibitory concentration; Hesperetin; Hesperetin-7-butyrate; Apoptosis; JNKs;
Keywords: Dual EGFR/HER2 inhibitors; Resistance; T790M/L858R mutant EGFR; Irreversible inhibitors; ADMET; Absorption/Distribution/Metabolism/Excretion/Toxicity; Cbl; Casitas B-lineage Lymphoma; c-MET; cellular mesenchymal to epithelial transition factor; DM; double
Keywords: Drug design; Microtubules; Microtubule-binding agents; Thiocolchicine; Tubulin structure; MT; Microtubules; MTBCs; MT-targeting bivalent compounds; MDA; microtubule depolymerizing agent; MSA; microtubule stabilizing agent; TH; thiocolchicine; THdim-S; sho
Keywords: Hybrid molecules; Anti-fungal; Anti-tubercular; Anti-malarial; anti-inflammatory; ACTs; artemesinin based combination therapy; CQ; chloroquine; CC50; concentration required to reduce growth by 50%; EC50; half maximal effective concentration; Fqa; ferroqui
Keywords: CAM; Complementary and Alternative Medicine; GI50; growth inhibition 50%; ED50; effective dose; IC50; inhibitory concentration 50%; EtOH; ethanol extract; Hex; hexane extract; EtOAc; ethylacetate extract; MeOH; methanol extract; DCM; Dichloromethane; PE;
Keywords: Phenolic compounds; Thio(seleno)semicarbazones; Antioxidants; ROS scavengers; Glycosidase inhibitors; Antiproliferative agents; AAPH; 2,2â²-azobis(2-amidinopropane) dihydrochloride; DPPH; 2,2-diphenyl-1-picrylhydrazyl, free radical; EC50; half maximal Ef
Polynuclear copper(II) complexes with nalidixic acid hydrazones: Antiproliferative activity and selectivity assessment over a panel of tumor cells
Keywords: Complex 1A or [Cu2(h2imi)Cl4]; Copper(II) complex synthesized from CuCl2 and 2-imidazolyl hydrazone; Complex 1B or [Cu3Cl4(h2imiâ)2H2O]; Crystal structure of the copper(II) complex synthesized from CuCl2 and 2-imidazolyl hydrazone; Complex 2A or [Cu3(h4
High MITF Expression Is Associated with Super-Enhancers and Suppressed by CDK7 Inhibition in Melanoma
Keywords: ChIP-seq; chromatin immunoprecipitation sequencing; CTD; carboxy-terminal domain; GI50; concentration at which half maximal inhibition of cell proliferation is achieved; GSEA; gene set enrichment analysis; MITF-hi; high MITF expression level; MITF-lo; low
Synthesis and SAR of new isoxazole-triazole bis-heterocyclic compounds as analogues of natural lignans with antiparasitic activity
Keywords: %GI; percentage of parasite growth inhibition at 100â¯Î¼M; GI50; 50% growth inhibition concentration; Bnz; benznidazole; MW; microwave; NA; not active at the tested concentration; ND; not determined due to absence of trypanocidal activity; SI; selectivit
An appraisal on synthetic and pharmaceutical perspectives of pyrazolo[4,3-d]pyrimidine scaffold
Keywords: A. flavus; Aspergillus flavus; C. albicans; Candida albicans; cAMP; cyclic adenosine monophosphate; CDK; cyclin-dependent kinase; CNS; central nervous system; COX; cyclooxygenase; CRF; corticotropin-releasing hormone; CRK; cdc2-related kinase; CYC6; cycli
Coordination chemistry of 1,3,5-triaza-7-phosphatricyclo[3.3.1.1]decane (PTA) and derivatives. Part III. Variations on a theme: Novel architectures, materials and applications
Keywords: PTA; 1,3,5-triaza-7-phosphatricyclo[3.3.1.1]decane; HPTA; 1-H-1,3,5-triaza-7-phosphatricyclo[3.3.1.1]decane; mPTA; 1-methyl-1,3,5-triaza-7-phosphatricyclo[3.3.1.1]decane; PTABn; 1-benzyl-1,3,5-triaza-7-phosphatricyclo[3.3.1.1]decane; PTAS; 1,3,5-triaza-7-
EB-3D a novel choline kinase inhibitor induces deregulation of the AMPK-mTOR pathway and apoptosis in leukemia T-cells
Keywords: AV; annexin V; CD3+; cluster of differentiation 3-positive cells; Cho; choline; ChoK; choline kinase; DEX; dexamethasone; FBS; fetal bovine serum; GI50; compound concentration required to inhibit cell growth by 50%; GPCho; glycerophosphocholine; l-ASP; l-
Celecoxib inhibits mitochondrial O2 consumption, promoting ROS dependent death of murine and human metastatic cancer cells via the apoptotic signalling pathway
Keywords: ÎÏm; mitochondrial transmembrane potential; t-BHP; tert-butyl hydroperoxide; COX-2; cyclooxygenase-2; DCFDA; 2â²,7â²-dichlorofluorescein diacetate; DHE; dihydroethidium; GI50; dose of drug causing 50% inhibition of cell growth by MTT assay; G + M + S;
Tithonia diversifolia (Hemsl.) A. Gray as a medicinal plant: A comprehensive review of its ethnopharmacology, phytochemistry, pharmacotoxicology and clinical relevance
Keywords: ABTS; 2,2â²-Azinobis (3-ethylbenzothiazoline-6-sulphonate); Ach; acetyl choline; ALP; alkaline phosphatase; ALT; alanine aminotransferase; AMPK; 5' adenosine monophosphate-activated protein kinase; AST; Aspartate transaminase; CAs; chlorogenic acids; CC5
Synthesis, characterization and in vitro biological assays of a silver(I) complex with 5-fluorouracil: A strategy to overcome multidrug resistant tumor cells
Keywords: [Ag3(fu)(fu-H)]; silver(I) complex with 5-fluorouracil; ATCC; American type culture collection; BHI; Brain and heart infusion; bp; base pair; CFU; colony-forming units; CLSI; Clinical and Laboratory Standards Institute; CP/MAS; cross-polarization magic an
Pyrrolopyrimidine derivatives and purine analogs as novel activators of Multidrug Resistance-associated Protein 1 (MRP1, ABCC1)
Keywords: ABC; ATP-binding cassette; ABCB1; synonymous for P-gp; ABCC1; synonymous for MRP1; ABCG2; synonymous for BCRP; APT; attached proton test; ATP; adenosine 5â²-triphosphate; BCECF; 2â².7â²-bis(2-carboxyethyl)-5-(and-6)-carboxyfluorescein; BCPCF; 3-carboxy
Dual Inhibition of Mnk2 and FLT3 for potential treatment of acute myeloid leukaemia
Keywords: Mnk inhibitor; FLT3 inhibitor; Dual inhibitor; AML; Drug discovery; Anti-leukaemic agent; AML; acute myeloid leukaemia; CDK; cyclin-dependent kinase; eIF; eukaryotic initiation factor; Erk; extracellular signal-regulated kinase; FLT3; Fms-like tyrosine ki
Synthesis, anti-proliferative activity, SAR study, and preliminary in vivo toxicity study of substituted N,Nâ²-bis(arylmethyl)benzimidazolium salts against a panel of non-small cell lung cancer cell lines
Keywords: NCI; National Cancer Institute; IC50; inhibitory concentration 50%; NSCLC; non-small cell lung cancer; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; SAR; structure-activity relationship; GI50; growth inhibition 50%; TGI; total growth
Selenoureido-iminosugars: A new family of multitarget drugs
Keywords: Glycosidase inhibition; Iminosugars; Selenoureas; AChE inhibition; Antioxidant; GPx mimic; AChE; acetylcholinesterase; CCT; chemical chaperone therapy; DNJ; 1-deoxynojirimycin; ERT; enzyme replacement therapy; GBA1; β-glucosidase acid 1; GI50; growth inh
Synthesis, in vitro antitumor activity, dihydrofolate reductase inhibition, DNA intercalation and structure-activity relationship studies of 1,3,5-triazine analogues
Keywords: DHFR; dihydrofolate reductase; ct-DNA; calf thymus DNA; NADPH; nicotinamide adenine dinucleotide phosphate; TGI; total growth inhibition; LC50; 50% lethal concentration; GI50; 50% growth inhibition; IC50; 50% inhibitory concentration; Ka; binding constant
Discovery of N-(benzyloxy)-1,3-diphenyl-1H-pyrazole-4-carboxamide derivatives as potential antiproliferative agents by inhibiting MEK
Keywords: MEK; mitogen-activated protein kinase; BRAF; V-RAF murine sarcoma viral oncogene homologue B1; ERK; extracellular regulated kinase; BRAFV600E; V600E mutant BRAF; BRAFV600K; V600K mutant BRAF; IC50; half maximal inhibitory concentration; GI50; the concentr
Anticancer and structure-activity relationship evaluation of 3-(naphthalen-2-yl)-N,5-diphenyl-pyrazoline-1-carbothioamide analogs of chalcone
Keywords: CoMFA; comparative molecular field analysis; CoMSIA; comparative molecular similarity index analysis; GI50; half-maximal cell growth inhibitory concentration; NDPC; 3-(naphthalen-2-yl)-N,5-diphenyl-pyrazoline-1-carbothioamide; Colorectal; Clonogenicity; Q
Fsn0503h antibody-mediated blockade of cathepsin S as a potential therapeutic strategy for the treatment of solid tumors
Keywords: Cathepsin S; Fsn0503h antibody; Cathepsin S blockade; Cell invasiveness; Colo-205 xenografts; ADCC; antibody-dependent cellular cytotoxicity; ANOVA; analysis of variance; Cat-S; cathepsin S; DMSO; dimethyl sulfoxide; ECM; extracellular matrix; Emax; maxim
The vascular disrupting activity of OXi8006 in endothelial cells and its phosphate prodrug OXi8007 in breast tumor xenografts
Keywords: ANOVA; analysis of variance; BLI; bioluminescence imaging; CA4; combretastatin A-4; CA4P; combretastatin A-4 phosphate; DAPI; 4â²,6-diamidino-2-phenylindole; DMSO; dimethyl sulfoxide; DTT; dithiothreitol; FAK; focal adhesion kinase; FDA; Federal Drug Adm
Biological evaluation of tanshindiols as EZH2 histone methyltransferase inhibitors
Keywords: EZH2; enhancer of zeste homologue 2; ELISA; enzyme-linked immunosorbent assay; IC50; half maximal inhibitory concentration; GI50; half maximal growth-inhibitory concentration; Ki; dissociation constant of the enzyme-inhibitor complex; EED; embryonic ect
Development of potent and selective Plasmodium falciparum calcium-dependent protein kinase 4 (PfCDPK4) inhibitors that block the transmission of malaria to mosquitoes
Keywords: Plasmodium falciparum; PfCDPK4; PfCDPK1; Pyrazolopyrimidine; Exflagellation; ACT; artemisinin combination therapy; ATP; adenosine triphosphate; Boc; tert-butyloxycarbonyl; CAMKII; Ca2+/calmodulin-dependent protein kinase II; CDPK1; calcium-dependent prote
Synthesis and biological evaluation of sorafenib- and regorafenib-like sEH inhibitors
Keywords: HCC; hepatocellular carcinoma; RCC; renal cell carcinoma; GI50; concentration required to inhibit cell growth by 50%; EpFAs; epoxygenated fatty acids; t-CUPM; trans-4-{4-[3-(4-chloro-3-trifluoromethyl-phenyl)-ureido]-cyclohexyloxy}-pyridine-2-carboxylic a
Characterisation of the roles of ABCB1, ABCC1, ABCC2 and ABCG2 in the transport and pharmacokinetics of actinomycin D in vitro and in vivo
Keywords: ABC transporter; ATP-binding cassette transporter; Act D; actinomycin D; ANOVA; analysis of variance; GI50; concentration at 50% growth inhibition; LC/MS; liquid chromatography/mass spectrometry; SEM; standard error of the mean; SNPs; single nucleotide po
Synthesis, biological evaluation and 3D-QSAR studies of novel 4,5-dihydro-1H-pyrazole niacinamide derivatives as BRAF inhibitors
Keywords: BRAF; V-RAF murine sarcoma viral oncogene homolog B1; BRAFV600E; V600E mutant BRAF; IC50; half maximal inhibitory concentration; GI50; the concentration that causes 50% growth inhibition; 3D-QSAR; quantitative structure-activity relationship; Synthesis;
A laccase-catalysed one-pot synthesis of aminonaphthoquinones and their anticancer activity
Keywords: Biocatalysis; Laccase; Oxidative enzymes; 1,4-Naphthohydroquinones; Aminonaphthoquinones; C–N bond formation; Primary amines; Monoamination; Anticancer agents; Cytostatic effects; Cytotoxic effects; GI50; TGI; LC50
Doing the methylene shuffle - Further insights into the inhibition of mitotic kinesin Eg5 with S-trityl l-cysteine
Keywords: Mitotic kinesins; Eg5; Antimitotic agents; STLC; Molecular dynamics; KSP; cLogD7.4; calculated LogD7.4; cLogS; calculated Log S, where S is the solubility in mol/L; DMEM; Dulbecco's Modified Eagle Medium; Et2O; diethyl ether; EtOAc; ethyl acetate; GI50
Evaluation of antitumor properties of novel saframycin analogs in vitro and in vivo
Keywords: Saframycin analog; GI50; DNA binding; Fluorescence; In vivo model
Inhibition of human telomerase by diphosphates of acyclic nucleoside phosphonates
Keywords: ANP; acyclic nucleoside phosphonate; ANPpp; ANP diphosphate; araGTP; 9-β-d-arabinofuranosylguanine 5â²-triphosphate; AZT-TP; 3â²-azido-3â²-deoxythymidine 5â²-triphosphate; CBV-TP; 2â²,3â²-didehydro-2â²,3â²-dideoxyguanosine 5â²-triphosphate; CdG-