Discovery of N-(benzyloxy)-1,3-diphenyl-1H-pyrazole-4-carboxamide derivatives as potential antiproliferative agents by inhibiting MEK

Twenty N-(benzyloxy)-1,3-diphenyl-1H-pyrazole-4-carboxamide derivatives have been designed and synthesized as MEK inhibitors, compound 7b showed the most potent inhibitory activity with IC50 of 91 nM for MEK1 and GI50 value of 0.26 μM for A549 cells.112