کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1376808 981966 2008 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Glycosidase profiling with immobilised glycosidase-inhibiting iminoalditols—A proof-of-concept study
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Glycosidase profiling with immobilised glycosidase-inhibiting iminoalditols—A proof-of-concept study
چکیده انگلیسی

Three typical glycosidase-inhibiting iminoalditols were attached to a polyamine surface displayed on a silicon chip. Exposure to a representative β-glucosidase revealed selective binding events reflecting the different structural features of the inhibitors probed in this study. This provides a proof-of-concept for the successful exploitation of microarrays of typical reversible glycosidase inhibitors of the iminosugar family.

The design of an iminoalditol chip and a proof-of-concept study by exposure of the microarray to β-glucosidase from Agrobacterium sp. is reported.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 6, 15 March 2008, Pages 1922–1925
نویسندگان
, , , , , , ,