کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1376832 981966 2008 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and antimicrobial activity of β-lactam–bile acid conjugates linked via triazole
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis and antimicrobial activity of β-lactam–bile acid conjugates linked via triazole
چکیده انگلیسی

Synthesis of novel 1,2,3-triazole-linked β-lactam–bile acid conjugates 17–24 using 1,3-dipolar cycloaddition reaction of azido β-lactam and terminal alkyne of bile acids in the presence of Cu(I) catalyst (click chemistry) have been realized. These molecules were evaluated in vitro for their antifungal and antibacterial activities. Most of the compounds exhibited significant antifungal and moderate antibacterial activity against all the tested strains.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 6, 15 March 2008, Pages 2043–2047
نویسندگان
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